The Best Vitamin K2 Supplement Brands +Its Fascinating Benefits

Written by Heidi Moretti, MS, RD, CLT — registered dietitian with 25+ years of clinical experience, author of the Fix Series, and a published letter-writer in JAMA Cardiology on vitamin K2 and coronary calcification research.

The best vitamin K2 supplement brands available on the market today are reviewed for you in this post, along with an honest look at what the newest research does — and doesn’t — support. Finding a quality vitamin K2 supplement matters, because most people are walking around deficient in this nutrient without knowing it. Vitamin K2’s health benefits for your bones, heart, and even your brain are explored here in detail.

As with any change to your healthcare routine, talk to your doctor or healthcare provider before adding vitamin K2, especially if you take blood thinners.

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Best vitamin K2 supplement, ranked

Overall best vitamin K2 supplements

1. Jarrow K-Right

With natural vitamin K2 derived from natto, Jarrow K-Right tops this list. It contains both natural kinds of vitamin K2 your body uses: the quick-acting menaquinone-4 (MK-4), which delivers benefits fast, and the longer-acting menaquinone-7 (MK-7), which is the form with the most clinical research behind it — including the 2026 coronary calcification trial discussed below.

This supplement contains the highest dose of full-spectrum vitamin K on this list: 500 mcg of vitamin K1, 1500 mcg of MK4, and 180 mcg of MK7, plus a modest dose of vitamin D3. Jarrow is a certified GMP company, meaning this product is optimized for quality and purity.

Pros: Highly rated and reputable company; highest concentration of vitamin K2 from vitaMK7®; 99% all-trans menaquinone-7 (the only active form of MK-7); no impurities; naturally sourced; third-party GMP certified; no fillers, using extra virgin olive oil, glycerin, gelatin, purified water, and organic caramel for color; two-month supply per bottle; made in the USA; soy-free and wheat-free.

Cons: GMO status not disclosed (though ingredients are unlikely to be genetically modified); priced higher than some competitors; not vegan.

Order Jarrow K-Right vitamin K2 supplement through my Fullscript dispensary →

2. Life Extension Super K

Life Extension Super K comes from a reputable company rated as a top supplement merchant among consumers on ConsumerLab.com. They offer a strong return policy and loyal repeat customers, and they even offer competitive pricing on lab test kits you can take to your local lab.

Its primary vitamin K2 comes from MK4, the form typically found in dairy — though you’d need to eat a large amount of grass-fed dairy to get a meaningful dose from food alone. It’s preserved with ascorbyl palmitate, a food-based form of vitamin C, to keep the product shelf-stable.

Pros: Highly rated; high dose of K2 as MK4 at 1000 mcg, MK7 at 100 mcg, and K1 at 1500 mcg per softgel; only trans-MK7, the most bioavailable form; non-GMO and gluten-free; manufactured in the USA; Certificate of Analysis available; third-party verified.

Cons: Does not contain vitamin D3; contains maltodextrin, which may bother people with sensitivities; not vegan.

Order Life Extension Super K vitamin K2 through my Fullscript dispensary →

3. Live Conscious K2 & D3

Live Conscious K2 + D3 supports bone health, heart health, and immune health. Vitamin K2 is an important cofactor for vitamin D3 to function optimally, and this supplement contains a good ratio of the two. The company also pledges to plant one million trees through the Eden Reforestation Project. It’s most cost-effective to buy directly from the company rather than through Amazon.

Pros: Natural MenaQ7® at 100 mcg per serving; therapeutic 5000 IU vitamin D3 per serving; all-natural ingredients; allergen-free; non-GMO; 60-day supply per bottle; hassle-free returns; free shipping.

Cons: Not vegan; occasional complaints about seal issues when purchased through Amazon; avoid if allergic to chickpeas; does not contain MK4.

Shop Live Conscious K2 & D3 supplement on Amazon →

Best vitamin K2 drops (the one I take)

4. Seeking Health Vitamin D3 + K2 Drops

Seeking Health’s Vitamin D3 + K2 Drops deliver 500 IU (12.5 mcg) of vitamin D3 and 50 mcg of vitamin K2 as MK-4 per drop, suspended in a simple olive oil base with no other fillers or additives. It’s soy-free, dairy-free, and gluten-free, and it’s free of the major allergens found in several of the other products on this list, which makes it an easy choice if you’re sensitive to extra ingredients.

Because it uses MK-4 rather than MK-7, this form clears your body faster (MK-4 has a half-life of just a couple of hours, versus roughly three days for MK-7). That means consistent daily use matters a bit more with this formula than with a longer-acting MK-7 product, but the tradeoff is a shorter, simpler ingredient list and an easy way to fine-tune your dose one drop at a time.

Pros: Clean two-ingredient formula (vitamin D3, vitamin K2 as MK-4, in an olive oil base); easy to dose precisely by the drop; no extra pill to swallow; free of dairy, egg, fish, shellfish, tree nuts, peanuts, wheat, and soy; suitable for vegetarians; widely used by functional and integrative practitioners.

Cons: Uses MK-4 instead of the longer-acting MK-7 studied in the 2026 coronary calcification trial; check with your healthcare provider before use if you’re on a blood thinner or have a history of high blood calcium.

Order Seeking Health Vitamin D3 + K2 Drops through my Fullscript dispensary →

Best vitamin K2 gummies

5. Zhou Vitamin D3 & K2 Gummies

Some people simply don’t like taking pills, so a gummy vitamin K2 is the way to go. The best gummy vitamin K2 is the Zhou Gummies D3+K2 brand — it’s the most affordable, all-natural, and gets great reviews for taste. Zhou is a Utah-based supplement company with lab verification of all incoming ingredients and finished products, meeting strict GMP certification criteria. Take it with a fat-containing meal, since vitamin K2 is fat-soluble.

Pros: 5000 IU (125 mcg) vitamin D3 and 90 mcg menaquinone; tastes great; GMP certified; made in the United States; 60 servings per bottle; bargain-priced; all-vegan.

Cons: Source of menaquinone isn’t listed; contains 1 gram of sugar.

Shop Zhou Vitamin D3 & K2 Gummies on Amazon →

6. Mary Ruth’s D3 & K2 Gummies

Mary Ruth’s D3 & K2 Gummies are flavored with peach, mango, and apricot, and reviewers consistently rate the taste highly. The natural K2 in this product comes from natto, which is commonly eaten in Japan as a natural source of vitamin K2. Most people don’t get enough K2 from food, so this is a good option for anyone looking to support heart and bone health. This product is appropriate for children ages 2 and up — as always, check with a healthcare provider first.

Pros: Highly rated for taste and quality; 60 servings per bottle; vegan formula with vitamin D3 at 25 mcg (1000 IU), vitamin K2 from lichen, 100 mg calcium, and 100 mcg vitamin K2 from natto; other ingredients include organic tapioca syrup, organic cane sugar, purified water, pectin, natural flavors, citric acid, sodium citrate, natural beta carotene, and organic sunflower oil; free of major allergens including dairy, wheat, and soy; safe for children 2+.

Cons: Contains 1 gram of sugar; the vitamin D3 dose may be lower than some people need.

Shop Mary Ruth’s D3 & K2 Gummies on Amazon →

Best vegan vitamin K2 supplement

7. Sports Research D3 & K2

Sports Research D3+K2 is a highly rated supplement featuring vegan vitamin K2 and vegan vitamin D3 derived from VegaDElight™ lichen, with vitamin K2 from MenaQ7®. This is the form of vitamin K2 most validated by research to date. The only other ingredients are virgin coconut oil and a vegan-certified PlantGel™ capsule, meaning no synthetic additives or fillers.

Pros: 5000 IU (125 mcg) vegan vitamin D3 and 100 mcg vitamin K2 as MK-7; made with VegaDElight™ (plant-based D3 from lichen) and MenaQ7® (patented MK7 from chickpea); 100% plant-based and vegan certified; non-GMO verified; soy, gluten, gelatin, and carrageenan free; contains organic coconut oil-derived MCTs; manufactured in a cGMP facility; made in the USA; 90-day money-back guarantee.

Cons: Avoid if you have a chickpea allergy.

Shop Sports Research Vegan D3 & K2 on Amazon →

Honorable mention

8. Doctor’s Best Natural MK7 + D3

Doctor’s Best Natural Vitamin K2 plus D3 is a reputable supplement with a modest amount of natural K2 as MK-7 MenaQ7®. This form helps inhibit calcification in cartilage and vessel walls, which — per the mechanism behind the 2026 JAMA Cardiology trial discussed below — may help protect against arterial calcification. It also contains a modest dose of supplemental vitamin D3 (cholecalciferol), which may support healthy blood pressure and heart function.

This product is a good value and contains a solid dose of vitamin K2, but includes more additives and fillers than the top picks on this list, which is why it lands as an honorable mention rather than a top-three pick.

Pros: Highly rated; GMP-certified company; high ratio of vitamin K2 to vitamin D3; uses the dose most frequently studied in clinical trials for K2 as MenaQ7®; 60-day supply; vegetarian; free of major allergens like gluten and soy; preserved with rosemary extract and vitamin C.

Cons: Contains maltodextrin, sucrose, magnesium stearate, and modified food starch; avoid if you have a chickpea allergy.

Shop Doctor’s Best Natural MK7 + D3 on Amazon →

How to choose the right vitamin K2 supplement

1. Check the form. Look for MK-7 (longer half-life, best studied for heart and bone) and/or MK-4 (fast-acting, more like the form found in animal foods). A blend of both, like Jarrow K-Right, covers more bases.
2. Look for a branded, clinically studied ingredient. MenaQ7® and vitaMK7® are the two names with the most published clinical trials behind them, including the 2026 coronary calcification trial.
3. Match the dose to your goal. Most bone and cardiovascular research uses 90 to 360 mcg per day of MK-7; higher doses used in Japanese menatetrenone research (45 mg/day) are pharmacologic and not typical of over-the-counter supplements.
4. Pair it with vitamin D3. The two nutrients work as partners — D3 helps your body build the proteins that K2 then activates.
5. Take it with a fat-containing meal. Vitamin K2 is fat-soluble and absorbs poorly on an empty stomach.
6. Talk to your doctor if you’re on warfarin or another blood thinner. Vitamin K2 can counteract these medications.

Why do you need vitamin K2?

If you’re eating leafy greens and believe you’re getting all the vitamin K you need, you’re only partly right. Vitamin K2 is a distinct nutrient that’s frequently missing in Western diets.

There are two classes of vitamin K: vitamin K1 and vitamin K2. From a health standpoint, vitamin K2 is the more broadly beneficial type. Within vitamin K2, the two best-known forms are menaquinone-4 (MK4) and menaquinone-7 (MK7). Vitamin K1, by contrast, is known as phylloquinone, and its role in health appears mostly limited to proper blood clotting.

Where do you get vitamin K2 in foods?

The highest source of vitamin K2 in any known food is a fermented soybean product called natto. Most people have never heard of natto, let alone eaten enough of it to get a meaningful dose. Natto delivers a specific type of vitamin K2 called menaquinone-7 (MK7).

Other fermented foods, like aged cheese, contain small amounts of vitamin K2. You’ll also get a little from leafy greens, since small amounts of vitamin K1 convert to vitamin K2 in the gut — though research is still unclear on exactly how much conversion happens.

Vitamin K2 also appears in small amounts in meats and dairy, especially grass-fed meats — this is the MK4 form of vitamin K2.

Factors that affect vitamin K2 levels

Vitamin K2 is fat-soluble, meaning it absorbs better when eaten with a fatty meal. It comes in many naturally occurring forms, including MK-4 through MK-11. Several factors can reduce how effectively your body uses vitamin K2:

• The quality and soil source of your food changes how much vitamin K2 it contains
• Inadequate vitamin D3 levels reduce vitamin K2’s effectiveness
• Poor magnesium intake
• Leaky gut or inflammatory bowel disease
• Cholesterol medications and certain other medications like antibiotics

Vitamin K2 bone health benefits

Research consistently shows that vitamin K2 helps build and maintain strong bones. Osteocalcin, a bone-building hormone, requires vitamin K2 to be activated, and vitamin K2 is far more effective at this than vitamin K1 — supplementing with K2 increases osteocalcin activation roughly 7 to 8 times more than the same dose of K1 research on vitamin K2 and osteocalcin activation.

A rigorous clinical trial found vitamin K2 improved bone density about as much as drug therapy clinical trial on vitamin K2 and bone density, and another trial found that 45 mg/day of vitamin K2 improved bone mineral content and femoral bone width in postmenopausal women over three years trial on vitamin K2 and bone mineral content in postmenopausal women.

A newer Frontiers in Endocrinology systematic review and meta-analysis, published in November 2025, pooled nine randomized controlled trials covering 2,570 postmenopausal women with osteoporosis. It found that K2 supplementation improved bone turnover markers including osteocalcin activation, and reduced markers of bone breakdown like TRAP and CTX 2025 meta-analysis on vitamin K2 and bone turnover markers. This builds on an earlier 2022 meta-analysis of 16 trials in 6,425 postmenopausal women, which found K2 helped maintain bone mineral density and reduced fracture incidence 2022 meta-analysis on vitamin K2 and bone mineral density. Together, these give a consistent — if still evolving — picture that K2 supports the biology of bone maintenance, even though not every individual trial has shown a significant fracture-risk reduction.

Related post: 5 Reasons Why Kids Need a Vitamin K2 Supplement

Vitamin K2 and cardiovascular health: what the 2026 trial actually found

This is the section of this post I’ve rewritten the most, because the evidence here changed substantially in 2026. A high intake of vitamin K2 has long been associated with reduced cardiovascular calcification, morbidity, and mortality across observational studies research on vitamin K2 and cardiovascular calcification, research on vitamin K2 and cardiovascular morbidity, research on vitamin K2 and cardiovascular mortality, but observational data can’t prove cause and effect the way a randomized trial can.

That’s what makes the VitaK-CAC trial such a meaningful addition. Published in JAMA Cardiology in June 2026, this was a two-year, double-blind, placebo-controlled randomized trial of about 180 adults in the Netherlands with mild-to-moderate coronary artery disease. Participants took 360 mcg/day of MK-7 (as MenaQ7®) or a placebo, and researchers tracked coronary artery calcification (CAC) progression by CT scan VitaK-CAC trial coverage on vitamin K2 and coronary calcification.

The results: the MK-7 group showed roughly 29% less progression in coronary artery calcification and 42% less progression in calcium mass score compared to placebo over two years reporting on the VitaK-CAC trial results for coronary artery calcification. Blood tests confirmed the proposed mechanism was active: participants taking MK-7 had higher circulating MK-7 levels and a smaller rise in dephosphorylated-uncarboxylated matrix Gla protein (dp-ucMGP), a marker of inactive, less-protective MGP study details on MK-7 and matrix Gla protein biomarkers.

I want to be direct about what this trial does and doesn’t show, because I’ve watched the supplement industry run away with headlines on studies like this before. Calcium scores increased in both groups — vitamin K2 slowed the rate of new calcification, it did not reverse existing plaque or calcium that was already there. This is a calcification-progression endpoint, not a hard outcome like heart attack or stroke, and the study population was adults with existing mild-to-moderate coronary artery disease, not healthy adults without cardiovascular disease. As one cardiology commentary on the trial put it, coronary calcification is a downstream feature of atherosclerosis, and slowing its progression doesn’t necessarily address the cholesterol deposition and inflammation that created the plaque in the first place cardiology commentary on vitamin K2 and coronary calcium.

I followed this trial closely enough that I wrote a formal letter to the editor published in JAMA Cardiology responding to it, where I disclosed a past relationship with NattoPharma (now part of Gnosis by Lesaffre, the company behind the MenaQ7® ingredient used in the trial). I think it’s an important, well-designed piece of evidence — one of the most rigorous trials to date specifically testing MK-7’s role in vascular calcification — but it’s one trial in one patient population, and I’d encourage anyone reading headlines about it to keep that context in mind rather than treating it as proof that K2 prevents heart attacks.

How does vitamin K2 help heart health?

Vitamin K2 activates proteins in the body called gla-proteins. One of these, matrix gla protein, helps regulate vascular smooth muscle cells and, essentially, helps keep calcium where it belongs — in the bones, not the arteries research on matrix Gla protein and vascular calcification.

Additional supporting research on vitamin K2 and heart health includes:

• Vitamin K2 blocks calcification of vascular smooth muscle cells research on vitamin K2 and vascular smooth muscle calcification
• MK-7 supplementation reduces arterial stiffness markers in postmenopausal women research on MK-7 and arterial stiffness in postmenopausal women
• A small study in patients with severe kidney disease found improved total and LDL cholesterol after K2 supplementation study on vitamin K2 and cholesterol in kidney disease patients

A 2017 study of 215 postmenopausal women receiving vitamin K2 over three years found reduced visceral fat, reduced body weight, and improved adiponectin levels, a marker involved in regulating glucose and fat metabolism 2017 study on vitamin K2 and visceral fat in postmenopausal women. Because that was a three-year study, its weight and fat-related benefits may be longer-lasting than shorter trials can capture.

Statin drugs inhibit vitamin K function, so in theory, K2 supplementation may help offset some negative side effects of statins research on vitamin K2 and statin drug interactions. If you’re on a statin or another cardiovascular medication, read more about which vitamins actually support heart health before adding anything new.

Vitamin K2 may reduce mitochondrial aging

Mitochondria are the powerhouses of energy production in most cells. Diseases of aging like Parkinson’s disease and other neurodegenerative conditions are linked to mitochondrial dysfunction. Vitamin K2 is highly concentrated in brain mitochondria, with high MK-4 activity found in brain astrocytes research on vitamin K2 and brain mitochondria.

Vitamin K2 and coenzyme Q10 share similar structures and both play roles in mitochondrial health. Vitamin K2 is crucial for energy formation, or electron transport research on vitamin K2 and electron transport, and this nutrient acts as an antioxidant that helps reduce mitochondrial aging across most cell types research on vitamin K2 and mitochondrial aging. High-dose vitamin K2 as menatetrenone has also been shown to significantly reduce fracture risk in Alzheimer’s patients, a disorder linked to mitochondrial dysfunction study on vitamin K2 and fracture risk in Alzheimer’s patients.

Vitamin K2 helps reduce diabetes complications

Type 2 diabetes accelerates aging in the body due to the damage caused by excess circulating glucose and, often, elevated inflammatory hormones. Diabetes is multifactorial, but nutrition is central to managing its effects.

Both vitamin K1 and K2 may reduce diabetes risk research on vitamin K1, K2 and diabetes risk, and one study found that high vitamin K2 intake was associated with reduced risk of metabolic syndrome and insulin resistance study on vitamin K2 intake and metabolic syndrome. A large Dutch study found both vitamin K1 and K2 were associated with about a 20% reduction in diabetes risk Dutch study on vitamin K intake and diabetes risk. A trial using menatetrenone at 90 mg/day (a pharmacologic, not supplemental, dose) versus placebo increased insulin sensitivity and carboxylated osteocalcin over four weeks and was well tolerated trial on menatetrenone and insulin sensitivity.

Vitamin K2 may help prevent kidney disease complications

Vitamin K2 deficiency in end-stage kidney disease increases the risk of aortic calcification by nearly three times research on vitamin K2 deficiency and aortic calcification. Three clinical trials of vitamin K2 in hemodialysis patients found improvements in matrix gla protein activity, which inhibits calcification. The first of these found most hemodialysis patients are deficient in vitamin K study on vitamin K deficiency in hemodialysis patients, and pharmacologic (large) doses of vitamin K were found safe and effective for improving matrix gla protein levels research on high-dose vitamin K and matrix Gla protein. Vitamin K2 also appears to reduce arterial stiffness in hemodialysis patients study on vitamin K2 and arterial stiffness in hemodialysis patients.

Vitamin K2 is not currently part of standard care for kidney disease patients, and many are on warfarin, so use needs to be discussed with a nephrologist first.

Related post: The Kidney Cleanse Diet: 15 Easy Diet Swaps to Improve Kidney Health

Vitamin K2 and cancer risk

Higher vitamin K2 intake has been associated with reduced risk of several cancers, including a 63% reduction in prostate cancer risk in one study study on vitamin K2 and prostate cancer risk. High intake of both K1 and K2 is linked to reduced all-cause mortality and reduced cancer rates overall research on vitamin K intake and cancer mortality. Vitamin K2 may increase survival rates and reduce recurrence in liver cancer (hepatocellular carcinoma) research on vitamin K2 and liver cancer survival, study on vitamin K2 and liver cancer recurrence, research on vitamin K2 and hepatocellular carcinoma. This research is preliminary, but vitamin K2 as part of a healthy lifestyle is likely to support a reduced risk of multiple cancer types.

Emerging vitamin K2 cancer research

In cell studies, vitamin K2 reduced cancer cell growth in triple-negative breast cancer cell study on vitamin K2 and breast cancer, research on vitamin K2 and triple-negative breast cancer cells, and showed similar benefits in prostate cancer cell study on vitamin K2 and prostate cancer, lung cancer, and leukemia cell studies research on vitamin K2 and leukemia cell studies. All of these cell studies are preliminary and haven’t yet been confirmed in humans.

Vitamin K2 and brain health: new 2025 research

Low overall vitamin K intake is associated with earlier onset of Alzheimer’s disease research on vitamin K intake and Alzheimer’s disease onset. This nutrient supports brain health partly because vitamin K2 is required to make sphingolipids, functional fats involved in neuron structure and cell signaling.

A 2025 review in Frontiers in Aging Neuroscience laid out the mechanisms in more detail: vitamin K2, via matrix gla protein, supports circulatory health and helps prevent calcification in the small blood vessels that supply the brain, and other vitamin K-dependent proteins help clear damaged cells and counteract neuroinflammation 2025 review on vitamin K2 and cognitive impairment. A separate 2025 paper on the epigenetic potential of vitamin K2 in brain health outlined how K2 may influence neuroinflammation, oxidative stress, and mitochondrial function relevant to Alzheimer’s disease specifically 2025 paper on vitamin K2 epigenetics and brain health.

Vitamin K2 also supports the formation of myelin, the protective coating around nerves. Animal research suggests vitamin K2 supplementation may reduce coronary calcification and improve lipid metabolism in ways that may also support brain health. Natto, rich in vitamin K2, reduces beta-amyloid development in the brains of animals animal study on natto and beta-amyloid, and a study in rats found K2 reduced anxiety and depressive symptoms rat study on vitamin K2 and anxiety symptoms. It’s too soon to say for certain that vitamin K2 works the same way in people, but the mechanistic and animal research is consistent enough that it’s a reasonable nutrient to prioritize for long-term brain health.

Vitamin K2 supplementation and dosing

No nutrient works in isolation — all nutrients work best in balance with each other. Vitamin K2 works better alongside adequate vitamin A and vitamin D status research on vitamin K2 and vitamin A synergy.

For a very thorough breakdown of vitamin K2 forms and dosing, visit Chris Masterjohn’s blog on vitamin K2.

Doses used in human studies vary widely, from small doses of 90 mcg up to large doses of 90 mg — about a 1,000-fold range — and all of these doses were found safe. In nature, vitamin K2 occurs in multiple forms. For a well-rounded supplement, it’s often wise to choose one containing both MK-4 and MK-7. Other menaquinone varieties exist but have far less research behind them so far.

Vitamin K2 risks

No toxicity has been documented for vitamin K from food or supplements, in any form of K1 or K2 research on vitamin K safety and toxicity. As a result, no upper safety limit for intake has been set. The recommended daily intake for vitamin K is 90 mcg for women and 120 mcg for men — though these recommendations don’t account for K2’s potential benefits beyond clotting.

If you’re on warfarin or another blood-thinning medication, check with your healthcare provider before adding any vitamin K. Otherwise, vitamin K2 is essentially non-toxic with no known adverse effects at supplemental doses, though you should avoid any product if you’re allergic to its ingredients.

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Heidi Moretti, MS, RD, CLT

Heidi Moretti, MS, RD, CLT is The Healthy RD. A registered dietitian for 25 years and author of the bestselling Cortisol Fix, Period Fix, Gut Fix, and The Whole Body Guide to Gut Health, Heidi has a passion for functional nutrition and natural medicine. She has researched supplements and natural medicine throughout her career, and one of her biggest loves is helping people gain function and vitality by tackling the root causes of illness.

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